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Supplementation with soluble dietary fiber has been shown to increase the abundance of beneficial bacteria while significantly reducing TMA and TMAO metabolism in red meat-fed mice (by 40.6% and 62.6%, respectively)

Therefore a systematic review and meta-analysis of the current published randomized control trials and observational studies were performed on this topic to assess whether GLP-1RAs expose the participants to the increased risk of the depressive events and the possible sources of the heterogeneity

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This could indicate complications such as pancreatitis, a rare but serious adverse effect associated with GLP-1 medications