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Extension (Rare): FDA needs more time
In the drugs best showing so far, the ATTAIN-1 trial, people taking orforglipron lost on average 12.4% of their baseline weight, a notch below the roughly 14% weight loss seen in similar trials of Novo Nordisks injectable Wegovy and also below the typical results seen with Eli Lillys tirzepatide, a dual GLP-1/GIP medication
6.4 Integrating reliable contraception into the prescription workflow Therefore, fertility planning and contraception should be a mandatory discussion item when initiating GLP-1RAs: patients must be informed of both the potential restart of their fertility and the specific circumstances under which oral contraceptive regimens may require adjustment
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