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GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

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Patients experiencing gastroparesis commonly report the following debilitating symptoms: Severe nausea and vomiting: Multiple daily episodes, unable to keep down liquids, leading to dangerous dehydration requiring emergency IV fluids Extreme early satiety: Feeling full after few bites, with food stuck in throat persisting hours Chronic abdominal pain and bloating: Persistent upper abdomen distention interfering with daily activities Dangerous weight loss: Inability to consume adequate calories causing vitamin deficiencies, muscle wasting, requiring feeding tubes Blood sugar fluctuations: Unpredictable glucose with nighttime lows followed by morning highs Diagnosing requires specific testing to measure gastric emptying

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