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Moreover, the application of machine learning and network analysis enables the identification of hub proteins from complex interaction maps, offering a data-driven foundation for personalized treatment strategies [450]

These include senolytics, which aim to block the transition of cells into a senescent state, and senoreversers, which promote the exit of senescent cells from this state [99]

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MALAT1-IN1, a preclinical-stage small-molecule inhibitor targeting MALAT1, abrogates its m 5 C modification, destabilizing the transcript and downregulating SLC7A11 expression to potentiate ferroptosis sensitivity