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Finally, while this study cannot definitively differentiate between central nervous system and peripheral effects of GLP-1RAs on alcohol intake, it does provide evidence that there is a role for peripheral mechanisms, which should be examined in future studies

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Cell Mol Gastroenterol Hepatol 4:3346 Zhao Y, Chen F, Wu W, Sun M, Bilotta AJ, Yao S et al (2018) GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3