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When a trainer crosses it, the trainer is exposed, but the patient is exposed more

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At the vascular and interstitial scale, insufficient perfusion and dense stromal architecture limit the ability of nanocarriers to enter tumor tissue and access deeper regions, making enhancement of functional perfusion and penetration a primary design concern [31, 33, 36]

Among them, MRI provides detailed information on soft tissues and vascular features, however, its relatively low sensitivity often necessitates the use of metal-based NPs as contrast agents to improve visualization and diagnostic performance [39]