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Compounded tirzepatide might be better tolerated by some people who struggle with semaglutide, though it can cause similar side effects

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Unlike FDA-approved medications, compounded drugs arent reviewed by the FDA for safety, effectiveness or quality before theyre marketed

The SURPASS-2 trial compared the efficacy and safety of tirzepatide at doses of 5 mg, 10 mg, and 15 mg, with those of semaglutide at a dose of 1 mg in patients with type 2 Diabetes over a period of 40 weeks [30]