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TRIUMPH-4, a separate trial in people with obesity and knee osteoarthritis, an older and more medically complex group, showed 28.7 percent weight loss at 68 weeks but a higher rate of people stopping treatment due to side effects, at 18.2 percent, compared with 11.3 percent in the TRIUMPH-1 group
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It can lead to: Dizziness or lightheadedness Blurred vision A brief feeling of faintness Increased heart rate Potassium Levels As a potassium-sparing diuretic, spironolactone can cause your body to hold onto too much potassium, a condition called hyperkalemia
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