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Limitations Follow-up studies should examine the same rating scales and biomarkers at later time points, including 6 months, 1 and 2 years after the acute infection, to delineate which patients show protracted chronic fatigue syndrome and GAD (which tend to be chronic disorders) and remitted depression (which most often comes in short-lasting episodes) [54, 105]

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If you have sensitive or reactive skin that has experienced irritation with hydroquinone, gentler options like niacinamide or low-concentration vitamin C may be better tolerated while still providing meaningful improvement

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