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Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]
It is still unclear whether microbiome changes drive metabolic improvements or simply reflect them
Veterans with obesity report poorer health status and more disability days compared to veterans without obesity
Compounded semaglutide does not undergo these trials, so there may be unknown risks
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