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Our results also indicate the potential involvement of the -catenin signaling pathway by showing the impact of Ex-4 on the expression of nuclear transcription factors SREBP-1, a key regulator of lipid metabolism in the liver 72 , and TCF4, a central transcription factor in the -catenin pathway, when -catenin is silenced
The gastrointestinal system contains a high concentration of GLP-1 receptors, which explains why digestive side effects are among the most commonly reported adverse reactions to semaglutide therapy
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