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B12 shots are one of the most effective forms of supplementation, because all of the vitamin is delivered into the bloodstream
B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet Supplementation with B vitamins could effectively reduce BW gain and plasma levels of lipids by improving energy metabolism-related enzyme activities in rats, thus possibly providing potential benefits to humans
While AOD-9604 is not FDA-approved as a prescription drug, it has received GRAS (Generally Recognized as Safe) status, indicating low toxicity and a good safety profile
"Systematic review and pragmatic clinical approach to oral and nasal vitamin B12 (cobalamin) treatment in patients with vitamin B12 deficiency related to gastrointestinal disorders"
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