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The peptide is engineered with a fatty-acid moiety to extend its circulation time (half-life ~6 days), allowing for once-weekly dosing [2]
By 6 months, many patients achieve 15-20 pounds of weight loss, and by one year, reductions of 20-30+ pounds are common in those who maintain consistent use and healthy lifestyle choices
Therefore, aggressive diuretic use and massive fluid restriction may be effective at reducing body weight for a short time, despite concerns of electrolyte imbalance and blood pressure drops during treatment
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