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Many people stay on maintenance doses indefinitely
The intake captures the FDA black-box contraindications including personal and family history for medullary thyroid cancer and MEN-2 syndrome alongside a 22-item comorbidity multi-select that includes pancreatitis history, severe depression, sleep apnea, T1/T2 diabetes, retinopathy, warfarin use, fatty liver, congestive heart failure, and PCOS
According to our current understanding of GLP-1RAs mitochondrial regulatory effect and oxidative stress suppression ability on eye diseases, the molecular pathways mainly involve the PINK1/Parkin-mediated mitophagy pathway and the GLP-1R-ERK1/2-HDAC6 signaling pathway (see Figure 3)
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