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The primary monotherapy dose-ranging evidence is a single trial: Lau and colleagues, published in The Lancet in 2021 (ClinicalTrials.gov NCT03856047 ) [5]
A turning point was the widespread vertical integration of PBMs with payers: by 2020, the three largest specialty pharmacies (CVS-Aetna, Express Scripts-Cigna, and Optum-UnitedHealth) were all part of insurers with captive specialty distribution ( [6] ) ( [19] )
First, reduced food intake means less dietary vitamin D from fatty fish, fortified dairy, and eggs
After glucose control and weight loss, GLP-1 drugs are now emerging as potential heart medicines with recent global trials showing they can lower chances of heart attacks and strokes in high-risk patients
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