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LY3437943 has shown a powerful effect in reducing liver fat and liver injury markers in obese mice, which may be attributed to a combination of GCGR's direct impact on the liver or the indirect effects resulting from weight loss

Lastly, a technical limitation of the current RNAScope work may be relevant, considering that in vitro co-culture experiments have demonstrated the ability of vagal sensory neurons to respond to enteroendocrine-derived glutamate

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