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Introduction Endoplasmic reticulum (ER) stress, which is well known as the accumulation of unfolded proteins in ER lumen caused by the increase of protein synthesis or multiple conditions, and ER responds to ER stress by activating the unfolded protein response (UPR), an adaptive intracellular signal to cope with ER stress and help to sustain cell survival and normal functions ( in vitro and vivo ( The small intestinal, which plays roles in nutrient digestion and absorption, and also acts as an innate barrier against luminal pathogens and physiological stress