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Terminal quantitative endpoints included plasma/liver biochemistry, liver histomorphometry and RNA sequencing

When people stop taking them, they are essentially taking their foot off the brake, and this can lead to rapid weight regain. The researchers say there are several reasons why people may not return to their original weight even a year after stopping the medications

Addressing these gaps will solidify BBRs position as a first-line phytotherapeutic for metabolic syndrome management

The no observed adverse effect level (NOAEL) was determined to be 540 mg/kg, equivalent to 24 times the human clinical dose (448 mg/person/28 days), supporting the safety margin of rotigotine behenate loaded in PLGA microspheres and its potential for advancement into phase I clinical trials for PD 137