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In animal experiments, researchers have found that the inactivation of Ubiquitin-Specific Peptidase 25(USP25) can alleviate oxidative liver injury induced by acetaminophen (APAP) overdose in male mice and reduce mortality caused by lethal doses of APAP
Additionally, the gut microbiota generates small molecule metabolites like indole and its derivatives, which possess anti-inflammatory and antioxidant properties and can protect the BBB from damage (Munoz-Pinto et al., 2024)
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