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at 1-800-845-8210 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch Drug Interactions Hepatic enzyme-inducing drugs (e.g., phenytoin, carbamazepine, phenobarbital, primidone, rifampin) can increase valproate clearance, while enzyme inhibitors (e.g., felbamate) can decrease valproate clearance

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6 Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, Peoples Republic of China *These authors contributed equally to this work Correspondence: Hailong Chen, Email [email protected] Abstract: The gut microbiota and its metabolites are bi-directionally associated with various human illnesses, which has received extensive attention

63 Additionally, ample GSH improves cell viability, whereas its depletion drastically increases susceptibility to ROS-inducing antibiotics