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The compound's effects on insulin sensitivity and triglyceride levels were specifically noted in clinical commentary, with researchers emphasizing that the aim of weight-loss therapy extends beyond weight reduction to include reduction in risk of type 2 diabetes, metabolic syndrome, and cardiovascular diseasegoals that tesofensine appears to address through its documented improvements in insulin sensitivity and triglyceride levels

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Chronic inflammation: Sustained immune activation that erodes tissues

Collectively, they can add 300 to 500 calories daily