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Here, we establish methodology for calculating occupancy of each receptor for clinically efficacious doses of the drug
In an environment characterized by oxidative stress and mitochondrial dysfunction, the presence of oxLDL further increases the secretion of proinflammatory cytokines (e.g., tumor necrosis factor , interleukin [IL]-6 and IL-1) and the expression of adhesion molecules (including vascular cell adhesion protein [VCAM]-1, monocyte chemoattractant protein [MCP]-1, intercellular adhesion molecule [ICAM]-1 and E-selectin) by monocytes and macrophages ( GLP-1 receptor stimulation appears to attenuate these processes in preclinical models and human studies in various ways
NEJM, 389, 22212232
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