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Current guidelines from the American Diabetes Association and European Association for the Study of Diabetes recommend combination SGLT-2 inhibitor plus GLP-1 RA therapy for patients with T2DM and established cardiovascular disease or high cardiovascular risk, based on additive cardiorenal benefits [20,21,22,23]
Some stem cell therapies have been aimed at direct replacement of neuronal cells lost during neurodegeneration (Chen et al., 2023a)
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