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doi: 10.7554/eLife.54818 21 YuWWangZZhangKChiZXuTJiangDet al
Targeting neuroinflammation: the therapeutic potential of -3 PUFAs in substance abuse
Mechanistically it adds steric and electrostatic bulk at the same end of the molecule the binding proteins engage, deepening the reduction in affinity beyond what the single substitution achieves alone
It is important to distinguish between dark urine caused by concentration (which appears deep yellow to amber and clears with increased fluid intake) and abnormal pigmentation suggesting pathology (such as tea-coloured urine indicating bilirubin, or red-brown urine suggesting blood or myoglobin)
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