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This temporary reaction occurs in approximately 5-10% of users and stems from the body's natural inflammatory response to the injection itself, not an allergy to the medication

The SURMOUNT-1 trial evaluating tirzepatide showed more pronounced effects, with participants losing 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) of body weight at 72 weeks

e , Left panel, representative images of p21 Cip1 IHC staining in PC3 tumours

This table reflects the general shape of a titration curve rather than a fixed protocol, since every patients schedule is individualized by their provider based on how they respond at each stage