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Regular review of treatment efficacy, tolerability, and safety is recommended, typically at 36 month intervals
Research showed that weight regain is common after discontinuing semaglutide (a common GLP-1 medication), with people regaining two-thirds of the weight they lost, and improvements in risk factors like blood pressure and HbA1c also reversed
Additionally, angiotensin II contributes to endothelial dysfunction by inducing expression of vascular endothelial growth factor and increasing reactive oxygen species, which reduce the bioavailability of vasodilators (such as nitrous oxide) responsible for maintaining normal glomerular vascular tone [14]
Medical food and food supplements: not always as safe as generally assumed
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