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10.1111/cpr.12575 103 WangL.ZhangB.ZhengW.KangM.ChenQ.QinW.et al (2017)

The single most important safety message applies to both routes: GLP-1 should be used only under the guidance of a qualified healthcare professional

For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose

Combination therapies, such as flunarizine plus topiramate and valproate plus magnesium, demonstrate superior efficacy and a lower incidence of adverse events compared to monotherapy