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Using gene-editing techniques, the researchers created mice whose GLP-1 receptors behaved more like human receptors, allowing them to study oral GLP-1 drugs, orforglipron (Foundayo) and an experimental oral GLP-1 called danuglipron
Textbook of Aging Skin, 2014: 1549-1566
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Although originally developed for the treatment of metabolic diseases, GLP-1-based therapies are now recognized for their influence on the same brain systems mediating drug-seeking and reward, suggesting therapeutic potential beyond glycemic control
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