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Contact your GP if cold sensations are accompanied by severe fatigue, unexplained weight loss beyond expected effects, heart rate changes, skin changes, shortness of breath, or swelling of the neck, as these may indicate thyroid dysfunction, anaemia, or other conditions requiring investigation

Int Immunopharmacol 61:2936 Staurengo-Ferrari L, Badaro-Garcia S, Hohmann MSN et al (2019) Contribution of Nrf2 modulation to the mechanism of action of analgesic and anti-inflammatory drugs in pre-clinical and clinical stages

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