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They may turn out to work well just as GLP-1s, synthetic insulin, and EPO work

The greater weight loss we observed suggests that menopausal hormone therapy may be an important modifier of response to tirzepatide, pointing toward a more personalized approach, where menopausal status and menopausal hormone therapy use is considered when counseling midlife women and designing treatment plans, Hurtado Andrade detailed

If a claim implies systemic benefits, treat it as a higher-uncertainty category and prioritise evidence quality over confidence

Continue working with your healthcare provider on appropriate analgesic strategies