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Semaglutide is a medication initially developed to treat type 2 diabetes by mimicking the hormone GLP-1, which regulates blood sugar levels and appetite
Thus it is not surprising that cortisol excess is associated with disturbed glucose homeostasis in patients with Cushings disease
Nevertheless, a 2018 study showed that less than 0.5% of the cells have GLP1R immunoreactivity, supporting a direct cell effect in a PKA-dependent manner [31]
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