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The BMAL1 knockout mouse (BMAL1/) model was used to explore the effects of circadian clock dysfunction on the GH circulating levels and downstream pathways (Steyn et al., 2011), the GH secretion profile in male mice is characterized by a high-amplitude pulse pattern for less than 30 min every 33.5 h with some variability
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doi: 10.1038/s41580-020-00288-9 Summary Keywords artificial intelligence, combined stresses, flavonoid regulatory networks, genome editing, phenylpropanoid metabolism, predictive metabolic engineering, stress adaptation Citation Hina A, Abbasi A, Chaudhry A, Sanaullah T, Arshad M, Sarwar HM, Sarfaraz S, Karikari B and Kavhiza NJ (2026) A review of flavonoids at the crossroads of plant defense: integrating biotic and abiotic stress tolerance through AI- and CRISPR/Cas-guided metabolic reprogramming
