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Central Nervous System Research Applications Standard rodent CNS protocols include middle cerebral artery occlusion (stroke model), controlled cortical impact (traumatic brain injury), cuprizone feeding (demyelination), and spinal cord compression
TL;DR: What the published dosing literature actually shows Rat data only, mostly: Effective doses in the rat literature span roughly six orders of magnitude, from 10 picograms per kilogram to 10 micrograms per kilogram, depending on model, route and endpoint
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