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Neuroinflammation: beneficial and detrimental effects after traumatic brain injury

Metformin works primarily by reducing hepatic glucose production (the amount of glucose released by the liver), improving insulin sensitivity in peripheral tissues, and modestly enhancing glucose uptake in muscles

Your Options After Reaching Target Weight: Continue at a maintenance dose (under medical supervision) Transition to lifestyle-only management Stay on treatment long-term (as needed for weight maintenance) Stopping treatment suddenly without support may lead to weight regain

For example, estrogen signaling has been shown to enhance the anorexigenic effects of GLP-1 RAs by modulating central pathways involved in food reward, which could account for the more pronounced weight loss observed in premenopausal women [49, 50]