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Go to the emergency room or urgent care if you experience: Your vomiting and diarrhea are severe Have signs of dehydration such as dizziness, extreme thirst, are peeing infrequently or have dark pee Significant abdominal pain that happens suddenly Have blood in your stool or vomit The Bottom Line GLP-1 medications can offer significant improvements in health, but they may not be suitable for everyone

Clinical efficacy remains equivalent across both formulations

But the researchers point out that the clinical trials for GLP-1 drugs excluded people with mood disorders and a history of suicide attempts leaving out those with bipolar disorder

Preclinical studies on bone specifically have shown consistent positive results