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Sixth, eGFR was calculated using the CKD-EPI 2009 equation to align with the SOUL trial
Although excitotoxicity results from exacerbated excitatory transmission, it is important not to forget the relevance of GABAergic transmission and how GABAergic system modulators may affect neuronal plasticity and/or protect against cognitive decline after brain insults
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These observations are based on animal and in vitro research models
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