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PMID 3046314

Urolithin A treatment has increased hippocampus neurogenesis, decreased reactive gliosis, and reduced inflammation in the middle cerebral artery occlusion mouse model of stroke [153]

Research highlights NAD+ Increased cellular NAD+ via nicotinamide pool NNMT Enzyme overexpressed in obese adipose tissue Anti-adip Reduced lipid accumulation and adipocyte differentiation SIRT1 Downstream sirtuin activation via NAD+ elevation Research notes Adipocyte research: In vitro models show reduced lipid accumulation and pre-adipocyte differentiation upon NNMT inhibition

A follow-up 2022 study examined NNMT inhibition combined with reduced calorie diet in DIO mice