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By selectively augmenting insulin release, modulation of GLP-1R trafficking may be a viable strategy to achieve greater metabolic control in T2D without increasing the rate of unwanted side effects, such as nausea
That may be true, but we also know that about 100 years of research show that structured lifestyle interventions lead to short-term weight loss but almost always long-term weight regain and so I am much more interested in 4-year outcomes in the STEP Trial participants and remain curious as to why they are choosing to follow and publicize this (cardiovascular trial) population instead
Immune cell recruitment genes were also elevated, including macrophage colony-stimulating factor receptors Csf1r (4.47-fold) and Csf2ra (6.43-fold), as well as T cell-related genes Il7r (17.25-fold)
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