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One small study in nondiabetic patients noted a 6.5% weight loss with sitagliptin versus 7.65% with metformin, but larger trials in type 2 diabetes have not shown a direct effect on body weight
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The FDAs determination to approve resmetirom was based on the findings of a phase 3 clinical trial (MAESTRO-NASH) that included a cohort of 966 patients with NASH 12
News reports note ongoing pressure from global use of semaglutide for diabetes and weight care
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