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The peptide molecule itself is large and the skin barrier limits penetration
B12 supplementation in elderly patients with confirmed deficiency typically takes two main forms in the UK: Oral tablets (cyanocobalamin) Intramuscular injections (hydroxocobalamin, the standard form in the UK) NICE Clinical Knowledge Summary guidance recommends investigating B12 deficiency in older adults presenting with unexplained anaemia, neuropathy, cognitive impairment, or glossitis
Davies MJ, Aroda VR, Collins BS et al (2022) Management of hyperglycaemia in type 2 diabetes, 2022
Professional societies like the Obesity Medicine Association (OMA) advise against compounded peptides because they lack clinical trials that prove their safety and efficacy
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