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Ebselen was found to increase the expression of GPX1 in SGNs after peroxynitrite damage, which is consistent with the reports that ebselen can increase the expression of GPX1 in cochlea after electrical stimulation ( gpx1 / mice leads to the aggravated SGN injury (cell loss and apoptosis) induced by peroxynitrite, although it might cause no effect on SGN development as SGNs presented normal morphology and cell number in gpx1 -deficient mice
They are medications that mimic GLP-1s, which are the main hormone involved in regulating glucose, signaling hunger, and balancing metabolic rate
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Increasing evidence suggests that immune dysfunction, abnormal expression of inflammatory cytokines, and gut microbiome dysbiosis are major contributors to IBD pathogenesis (161, 162)
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