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Semaglutide is administered as a once-weekly subcutaneous injection , while liraglutide is taken once daily

It has been shown that the stimulatory effect of GLP-1 on insulin secretion is, to some extent, dependent on PKC, as evidenced by the ability of the PKC activator phorbol 12-myristate 13-acetate to mimic the effects of GLP-1 on electrical activity

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The thigh has some practical advantages