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Niciu MJ, Ionescu DF, Mathews DC, Richards EM, Zarate CA

The pharmacodynamics of ALT-801, a GLP-1/glucagon receptor dual agonist optimized for NASH and weight loss, were compared to semaglutide (GLP-1 receptor agonist) and elafibranor (peroxisome proliferator-activated receptor, PPAR-/, agonist) in a biopsy-confirmed, diet-induced obese (DIO) mouse model of NASH (DIO-NASH)

Soluble fiber and resistant starch are secondary GLP-1 activators that work through a different mechanismthey feed beneficial gut bacteria that produce short-chain fatty acids, which in turn stimulate L-cell secretion

A significant advantage of PEG-MGF is its extended half-life, allowing for continuous effects over several hours