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These specialized regions relay peripheral signals into deeper brain areas without direct engagement of preproglucagon (PPG) neurons, which constitute the brains endogenous GLP-1 source (McLean et al., 2021)

This finding positioned GLP-1 receptor agonists not merely as metabolic drugs but as cardiovascular therapeutics, a distinction that carries particular relevance for menopausal women, whose cardiovascular risk accelerates significantly during and after the transition

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The most significant interaction involves other glucose-lowering drugs