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Furthermore, the REWIND trial demonstrated a 12% reduction in major adverse cardiovascular events (MACE) ( p = 0.026), including among patients without established cardiovascular disease, alongside renoprotective effects evidenced by reductions in albuminuria [56]
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The inconsistent results may be due to the low incidence and the incorporation of studies with limited sample sizes, statistical effectiveness was not greatly increased
This can sometimes be confused with appendicitis
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