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In addition to weight loss, some GLP-1 medications can reduce cardiovascular risk and help treat conditions such as fatty liver disease and obstructive sleep apnea
However, safety depends on several factors: injection site rotation to avoid lipodystrophy, adequate hydration (both agents can increase fluid demand), and monitoring of B vitamin status since semaglutide may affect nutrient absorption slightly during rapid weight loss phases
Increase in activity during calorie restriction requires Sirt1
Diabetes 15 , 30 (2025)
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