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A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss
Parajuli, N
Patients with clinically confirmed deficiencies may begin with weekly injections and then transition to a maintenance schedule
5-Amino-1MQ is a small-molecule NNMT enzyme inhibitor
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