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Using a drug off-label means using it for something other than its FDA-approved use

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Mounjaro became licensed and approved for weight loss in the UK in November 2023, Mounjaro has been approved for weight loss if you have: a BMI (body mass index) of 30 kg/m or higher (obesity) a BMI between 27 and 30 kg/m (overweight) and a weight-related health condition, such as high cholesterol, high blood pressure, prediabetes, or heart problems Sources Mounjaro KwikPen 2.5/5/7.5/10/12.5/15 mg solution for injection in pre-filled pen, emc [accessed 30 June 2026] MHRA authorises diabetes drug Mounjaro (tirzepatide) for weight management and weight loss, GOV.UK [accessed 30 June 2026] How to use Mounjaro, Mounjaro [accessed 30 June 2026] Obesity, NHS [accessed 30 June 2026] Tirzepatide Once Weekly for the Treatment of Obesity, The New England Journal of Medicine [accessed 30 June 2026] Continued Treatment With Tirzepatide for Maintenance of Weight reduction in Adults With Obesity, Journal of the American Medical Association [accessed 30 June 2026] Weight management injections, NHS England [accessed 30 June 2026] Once-Weekly Semaglutide in Adults with Overweight or Obesity, NEJM [accessed 30 June 2026] FSRH Statement: Glucagon-like peptide-1 (GLP-1) agonists and oral contraception, The Faculty of Sexual & Reproductive Healthcare [accessed 30 June 2026] Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity, New England Journal of Medicine [accessed 30 June 2026] Wegovy tablet, EMC [accessed 30 June 2026] Medically reviewed by Dr Nicholas Antonakopoulos Chief Medical Officer (MBBS, BSc), GMC Number: 6149065 Last reviewed: 30 Jun 2026 Related weight loss treatments Delivery Regulated for your safety ZAVA is regulated by the same UK healthcare bodies that oversee GP practices, pharmacies and NHS services

101 The Role of Impaired BBB in Diabetes and Obesity with GLP-1RAs and SGLT-2is DM and obesity influence BBB integrity through a number of mechanisms (Figure 4)