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For example, when histamine binds to a receptor on endothelial (blood vessel) cells, it causes vascular permeability, resulting in swelling and inflammation
H.NakagawaT.FengL.WatanabeS.HanL.MazzaliM.et al (2002)
That kind of reliability over an extended period tells us the compound holds its effectiveness month after month
PPIs do not meaningfully affect this absorption because isotretinoin is lipophilic, not pH-dependent
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