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There are seven different types of senolytic drug that target BCL-2 proteins (navitoclax and venetoclax), tyrosine kinase/BCL-2 (dasatinib/quercentin), antioxidants (fisetin), HSP90 inhibitors (17-DMAG/IPI504), the p53 pathway (UBX0101/Foxo4-DRI peptide), Na + /K + ATPase (cardiotonic steroids) and galactosidase prodrugs (GMD/SSK1) 112
In the semaglutide group, kidney function declined more slowly than in the group given a placebo
We did not require elevated NT-proBNP as an eligibility criterion, and thus, NT-proBNP levels in SUMMIT were only slightly elevated on average (median 175 ng l 1 ), and accordingly, there was little margin for further reduction
Mohammad Karim A
